Premium
Prolactin‐secreting pituitary carcinoma with implants in the cheek pouch and metastases to the ovaries. A case report and literature review
Author(s) -
Gollard Russell,
Kosty Michael,
Cheney Carol,
Copeland Brian,
Bordin Gerald
Publication year - 1995
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19951115)76:10<1814::aid-cncr2820761021>3.0.co;2-t
Subject(s) - medicine , debulking , radiation therapy , prolactin , pathology , cancer , ovarian cancer , hormone
Background . Prolactin‐secreting pituitary carcinomas are uncommon, locally destructive neoplasms that rarely metastasize outside the central nervous system. The authors report a case of a prolactin‐secreting tumor that initially presented as the empty sella syndrome. Two recurrences along transsphenoidal surgery tracts in cheek pouches were followed by distant metastases later in the abdomen and pelvis. Only 10 previous cases of either extracranial or intracranial metastases from prolactin‐secreting pituitary carcinomas have been reported. No metastases below the diaphragm have been reported previously. Methods . The patient's cheek pouch implants, lymph node metastases, ovarian metastases, and uterine metastases were studied with prolactin‐specific immunohistochemistry. Results . Long term treatment with bromocriptine, several debulking surgeries, extensive local radiation therapy (external beam and proton beam), and cytotoxic chemotherapy had little impact. Tamoxifen, however, may have slowed tumor growth. Conclusion . Tamoxifen may have efficacy in the treatment of prolactin‐secreting pituitary carcinomas. Cancer 1995;76:1814–20.