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Proliferating cell nuclear antigen and Ki‐67 immunohistochemistry of oligodendrogliomas with special reference to prognosis
Author(s) -
Heegaard Steffen,
Sommer Helle M.,
Broholm Helle,
Brœndstrup Otto
Publication year - 1995
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19951115)76:10<1809::aid-cncr2820761020>3.0.co;2-i
Subject(s) - proliferating cell nuclear antigen , immunohistochemistry , medicine , ki 67 , pathology , nuclear atypia , atypia , biopsy , staining , correlation , nuclear medicine , geometry , mathematics
Background . The biologic behavior of oligodendrogliomas is somewhat unpredictable. A supplementary prognostic factor is, therefore, desirable. Methods . Thirty‐two pure supratentorial oligodendrogliomas were investigated using proliferating cell nuclear antigen (PCNA) and Ki‐67 immunohistochemical analyses. The correlation of PCNA and Ki‐67 labeling index (LI) with prognosis were studied, and the correlation of LI with clinical data was evaluated. Results . The PCNA LI had a range of 0–17% (mean, 5.27%; standard deviation [SD] = 4.65), and the Ki‐67 LI had a range of 0–29% (mean, 4.19%; SD = 5.66). In general, the PCNA LI seemed to be higher than the Ki‐67 LI. The mean survival time was 4.4 years, and 5‐ and 10‐year survival rates were 38% and 19%, respectively. Ki‐67 and PCNA staining indicated that patients with a high LI (>3% and >4%, respectively) had a significantly higher mortality, with mean survival time of 23.5 months and 26.2 months, respectively. No significant correlation between LI (or survival) and tumor size, cerebral localization, radiation, resection/biopsy, sex, age, or cytologic atypia was found. Conclusions . The use of Ki‐67 and PCNA LI higher than 3% and 4%, respectively, appears reliable as prognostic factors when investigating pure supratentorial oligodendrogliomas. Cancer 1995; 76:1809–13.