Premium
Blood flow and metabolism of central neurocytoma. A positron emission tomography study
Author(s) -
Mineura Katsuyoshi,
Sasajima Toshio,
Itoh Yasunobu,
Sasajima Hiroyasu,
Kowada Masayoshi,
Tomura Noriaki,
Uesaka Yoshiyuki,
Ogawa Toshihide,
Hatazawa Jun,
Uemura Kazuo
Publication year - 1995
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19951001)76:7<1224::aid-cncr2820760720>3.0.co;2-r
Subject(s) - central neurocytoma , cerebral blood flow , medicine , positron emission tomography , nuclear medicine , fluorodeoxyglucose , blood flow , brain tumor , white matter , pathology , radiology , magnetic resonance imaging
Background . New World Health Organization classifications have categorized central neurocytomas as neuronal tumors. The differential diagnosis between central neurocytomas and other tumors is important for selection of the optimal therapy modality for the management of intraventricular tumors. To characterize the pathophysiology and proliferating activity of central neurocytoma accurately, cerebral blood flow and metabolism in five patients with central neurocytoma were studied using positron emission tomography (PET). Methods . Tracers used for the present study included C 15 O 2 , C 15 O, 15 O 2 , and 18 F‐fluorodeoxyglucose (FDG). Regional cerebral blood flow (rCBF), cerebral blood volume (rCBV), oxygen extraction fraction (rOEF), cerebral metabolic rate of oxygen (rCMRO 2 ), and cerebral metabolic rate of glucose (rCMRGl) were quantitatively analyzed in tumor lesions and the contralateral gray matter. Four patients with central neurocytoma underwent a complete PET study, including all circulatory and metabolic parameters; one patient was studied with 11 C‐methyl‐L‐methionine and FDG tracers. Results . Tumor rCBF and rCBV were higher than comparable values in the contralateral gray matter in three of four patients. This high level of perfusion corresponds to angiographic findings that show intense tumor staining in tumors fed by perforated arteries. Tumor rOEF and rCMRO 2 were significantly lower than corresponding values in the gray matter (rOEF, P < 0.01; rCMRO 2 , P < 0.05 by Student's t test). Tumor rCMRGl ranged from 2.68 to 6.26 mg/100 ml/minutes and did not exceed contralateral gray matter values in any of the five patients. Tumor rCMRGl was significantly lower ( P < 0.02) than the gray matter rCMRGl. One tumor exhibited a relatively high value of rCMRGl (comparable to gray matter rCMRGl), and increased in size 4 months after partial resection. No other tumors appeared during postoperative follow‐up periods that ranged from 4 to 135 months. Conclusions . Circulation and metabolism parameters measured by PET offer insight into the biologic characteristics of central neurocytoma. Tumor rCMRGl may be an indicator of the proliferating activity in central neurocytoma.