Premium
Thrombosis of tibial arteries in a patient receiving tamoxifen therapy
Author(s) -
Deshmukh Narayan,
Tripathi Sanjay P.
Publication year - 1995
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19950915)76:6<1006::aid-cncr2820760614>3.0.co;2-k
Subject(s) - medicine , tamoxifen , thrombosis , breast cancer , venous thrombosis , surgery , adjuvant therapy , mastectomy , urokinase , hormone therapy , cancer , chemotherapy
Background . Tamoxifen has been used extensively as adjuvant therapy in the treatment of pre‐ and postmenopausal patients with breast cancer. One of its known complications is venous thromboembolism. However, arterial thrombosis has been reported rarely. Methods . A 49‐year‐old patient with breast cancer had had a total mastectomy 3 years earlier. She was receiving tamoxifen therapy when she developed a sudden onset of pain and numbness of the left foot and calf. An arteriogram showed thrombosis of her tibial arteries. Results . This thrombosis was lysed successfully with urokinase therapy, and tamoxifen therapy was discontinued. At follow‐up 4 months later, the patient had normal circulation to both legs. Conclusions . Patients receiving tamoxifen should be monitored closely for the development of venous or arterial thromboembolism. Cancer 1995;76:1006–8.