Premium
Biphasic synovial sarcoma in the small intestinal mesentery
Author(s) -
Helliwell Timothy R.,
King Andrew P.,
Raraty Michael,
Wittram Conrad,
Morris Anthony I.,
Myint Sun,
Hershman Michael J.
Publication year - 1995
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19950615)75:12<2862::aid-cncr2820751211>3.0.co;2-q
Subject(s) - synovial sarcoma , pathology , vimentin , desmin , immunohistochemistry , mesentery , medicine , in situ hybridization , sarcoma , fluorescence in situ hybridization , malignancy , biology , biochemistry , gene expression , chromosome , gene
Background. A 46‐year‐old man presented with recurrent anemia and polyarthralgia. Investigations revealed a mass in the ileal mesentery, which was resected. Results of routine histologic examination suggested a diagnosis of synovial sarcoma, a rare malignancy usually not reported at this site. Methods. Tissue was examined immunohistochemically, ultrastructurally, and by fluorescent in situ hybridization to confirm the diagnosis. Results. Immunohistochemical studies revealed widespread labeling for cytokeratins and focal labeling for desmin and vimentin in the epithelial component, with labeling for epithelial membrane antigen in the epithelial and spindle‐cell components. Fluorescent in situ hybridization analysis showed the characteristic t(X;18) translocation of synovial sarcoma. Conclusions. This is a unique case of synovial sarcoma in the small intestinal mesentery. Immunohistochemical labeling confirmed the diagnosis, although, to the authors' knowledge, the pattern of desmin labeling has not been described previously. The clinical association with polyarthralgia, which resolved after removal of the neoplasm, also has not been described previously. Cancer 1995;75:2862–6.