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Flow cytometric analysis of the dna content of adenocarcinoma of the lung, especially for patients with stage 1 disease with long term follow‐up
Author(s) -
Tanaka Isao,
Masuda Ryo,
Furuhata Yoshiaki,
Inoue Masaharu,
Fujiwara Mutsunori,
Takemura Tamiko
Publication year - 1995
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19950515)75:10<2461::aid-cncr2820751011>3.0.co;2-d
Subject(s) - medicine , stage (stratigraphy) , adenocarcinoma , disease , term (time) , lung , lung disease , pathology , oncology , cancer , biology , physics , quantum mechanics , paleontology
Background . To assess the prognostic value of DNA ploidy in adenocarcinoma of the lung, the authors performed a flow cytometric study using paraffin embedded archival material from 160 patients (109 [68%] with aneuploid lesions, 51 [32%] with diploid lesions) who underwent surgical resection from 1982 to 1991. Methods . The proportion of DNA aneuploid tumors increased as the disease stage advanced, from 35 of 63 (55.5%) with Stage 1 disease to 15 of 20 (75.0%) with Stage 2 disease, to 40 of 53 (75.5%) with Stage 3a disease, to 19 of 24 (79.2%) with Stage 3b disease. However, this trend was not statistically significant. Comparison of the survival time of the 160 patients with adenocarcinoma of the lung with a median follow‐up of 7.8 years revealed that patients with diploid tumors had significantly longer survival than did those with aneuploid tumors {P < 0.01). Results . Examination by stage showed that patients with Stage 1 disease with diploid tumors had significantly longer survival times than did those with aneuploid tumors (P < 0.05) but that there were no significant differences in clinical outcome in patients with Stage 2, 3a, and 3b diploid tumors. Conclusions . Analysis of aneuploid versus diploid DNA content in patients with Stage 1 adenocarcinoma of the lung is concluded to be useful in evaluating clinical outcome and prognosis.