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10.5‐kb homozygote of tumor necrosis factor‐beta gene is associated with a better prognosis in gastric cancer patients
Author(s) -
Shimura Tatsuo,
Hagihara Masao,
Takebe Kentaro,
Munkhbat Batmunkh,
Ogoshi Kyoji,
Mitomi Dd Toshio,
Nagamachi Yukio,
Tsuji Kimiyoshi
Publication year - 1995
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19950315)75:6+<1450::aid-cncr2820751510>3.0.co;2-v
Subject(s) - heterozygote advantage , gastroenterology , medicine , cancer , lung cancer , allele , restriction fragment length polymorphism , genotype , microbiology and biotechnology , gene , pathology , biology , genetics
Background . In NcoI restriction fragment length polymorphism analysis of tumor necrosis factor‐beta (TNF‐β) gene, the frequency of 10.5‐kb homozygote is low in patients with lung cancer and is associated with a better prognosis. These results should be examined in other malignancies. Methods . Using polymerase chain reaction, the authors performed NcoI restriction fragment length polymorphism analysis in 152 patients with gastric cancer, in 69 patients with benign gastric lesion, and in 141 healthy volunteers. Results . In 3‐year survival, the 10.5‐kb homozygote showed a better prognosis (87.1%) than other alleles (5.5‐kb homozygote, 52.5%; heterozygote, 79.1%), and there was a statistically significant difference between the 10.5‐kb homozygote and the 5.5‐kb homozygote. In 3‐year survival for Stages III and IV, the 10.5‐kb homozygote also showed a better prognosis (64.9%) than other alleles (5.5‐kb homozygote, 16.7%; heterozygote, 41.4%). There were statistically significant differences (10.5‐kb homozygote vs. 5.5‐kb homozygote, P < 0.01; heterozygote vs. 5.5‐kb homozygote, P < 0.05). There was a statistical difference between all patients and Stages III and IV ( P < 0.05). Conclusions . The 10.5‐kb homozygote of TNF‐β gene is associated with a prolonged survival in patients with gastric cancer, as has been shown in the patients with lung cancer. Cancer 1995;75:1450‐3.