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Molecular genotyping for N‐acetylation polymorphism in Japanese patients with colorectal cancer
Author(s) -
Shibuta Kenji,
Nakashima Tadasu,
Abe Masako,
Mashimo Masami,
Mori Masaki,
Ueo Hiroaki,
Akiyoshi Tsuyoshi,
Sugimachi Keizo,
Suzuki Tomokazu
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19941215)74:12<3108::aid-cncr2820741208>3.0.co;2-m
Subject(s) - genotyping , colorectal cancer , genotype , medicine , acetylation , genetics , polymorphism (computer science) , allele , polymerase chain reaction , restriction fragment length polymorphism , oncology , cancer , biology , gene
Background . N‐acetylation polymorphism has been documented as a representative pharmacogenetic trait, and also has been implicated ecogenetically in an individual's susceptibility to cancer. However, there still remains controversy concerning the association between colorectal cancer and N‐acetylation polymorphism. Methods . A newly established molecular genotyping method using polymerase chain reaction‐based restriction fragment length polymorphism to analyze the distribution of polymorphism in a large group of Japanese patients with colorectal cancer was used. Results . Based on an analysis of 234 Japanese patients with colorectal cancer and 329 healthy control subjects, no significant difference was observed in either the distribution of acetylator phenotypes or of allele frequencies between the two groups. In addition, no significant difference in their distribution was found based on the age at which cancer was first detected, the location of tumors, or the histopathologic features. Conclusions . N‐acetylation polymorphism does not appear to be implicated crucially as a genetic trait affecting an individual's susceptibility to colorectal cancer.