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The multicentric occurrence of squamous epithelial dysplasia and squamous cell carcinoma in the esophagus
Author(s) -
Morita Masaru,
Kuwano Hiroyuki,
Yasuda Mitsuhiro,
Watanabe Masayuki,
Ohno Shinji,
Saito Takao,
Furusawa Motonosuke,
Sugimachi Keizo
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19941201)74:11<2889::aid-cncr2820741102>3.0.co;2-k
Subject(s) - esophagus , medicine , dysplasia , carcinoma , basal cell , pathology , lesion , incidence (geometry) , gastroenterology , carcinoma in situ , epidermoid carcinoma , epithelial dysplasia , physics , optics
Background . The biologic significance of esophageal dysplasia has not yet been completely elucidated, especially regarding the process of multiple occurrences of squamous cell carcinoma. Methods . The multiplicity of dysplasia in 73 patients with solitary carcinoma of the esophagus (Group I) and 21 with multiple carcinomas (Group II)was compared in surgically resected specimens. Results . Thirty‐nine second carcinomas were identified in 13 patients of Group II, and all were superficial. The incidences of five or more isolated dysplasias in cases without continuity to a carcinomatous lesion, was 6.8% and 66.7% in Groups I and II, respectively ( P < 0.01). In a case with three or more carcinomas, the incidence increased to 84.6%. The coexistence of all grades of isolated dysplasias was observed in 10 patients (47.6%) in Group II but in only 6 patients (8.2%) in Group I ( P < 0.01). Conclusions . These findings suggest that various degrees of evolving biologically related lesions, such as dysplasia and carcinoma, can occur multicentrically in the same esophagus.