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Changes in Tc‐99m radionuclide bone scan images and peripheralizatioin of marrow hematopoetic activity associated with the administration of granulocyte colony stimulating factor as an adjunct to dose‐intensified chemotherapy for breast cancer
Author(s) -
Salgia Ravi,
Demetri George D.,
Kaplan William D.
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19941001)74:7<1887::aid-cncr2820740710>3.0.co;2-6
Subject(s) - medicine , chemotherapy , granulocyte colony stimulating factor , bone marrow , granulocyte , hematopoietic growth factor , neutropenia , haematopoiesis , breast cancer , mammary gland , oncology , cancer , stem cell , biology , genetics
Granulocyte colony stimulating factor (G‐CSF) is used clinically for chemotherapy‐associated neutropenia. Very little is known about the manner in which pharmacologic dosing of G‐CSF may affect radiologic studies in vivo. Dramatic changes on bone scan associated with the administration of G‐CSF used to support dose‐intensified combination chemotherapy in a patient with metastatic breast carcinoma are described. The scintigraphic findings were correlated histologically with increased hematopoietic activity in the bone marrow located in peripheral bones.