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Autologous bone marrow transplantation in children with advanced neuroblastoma
Author(s) -
Mugishima Hideo,
Iwata Mitsumasa,
Okabe Ikuo,
Sanuki Eiichi,
Onuma Naomi,
Fujimoto Takeo,
Ohira Mutsuro,
Kaneko Michio,
Tsuchida Yoshiaki,
Okuni Masahiko
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19940801)74:3<972::aid-cncr2820740329>3.0.co;2-3
Subject(s) - medicine , neuroblastoma , chemotherapy , bone marrow , surgery , autotransplantation , transplantation , radiation therapy , confidence interval , survival rate , oncology , genetics , biology , cell culture
Background . Encouraging results have been reported with high dose chemotherapy and total body radiation followed by bone marrow autotransplantation in children with advanced neuroblastoma; however, relapse remains a significant problem. Methods . The authors treated 22 children with advanced neuroblastoma with high dose chemotherapy, surgery, intraoperative radiation, and a bone marrow autotransplant (treated in vitro to remove tumor cells) followed by 13‐cis‐retinoic acid. Results . The 3‐year relapse rate was 25% (95% confidence interval [CI], 6‐44%). The 3‐year disease free survival rate was 72% (95% CI, 52‐92%). Toxicities included hemolytic uremic syndrome, herpes infection, and hepatic venoocclusive disease. Conclusion. These data suggest that this treatment strategy offers an increased rate of 3‐year disease free survival. The nonrandomized nature of this study and its use of multiple modalities precludes the analysis of the specific contribution of each treatment component and comparison with conventional therapy. Cancer 1994; 74: 972‐7.