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Inhibition of 5 ‐ fluorouracil‐induced ocular irritation by ocular ice packs
Author(s) -
Loprinzi Charles L.,
Wender Donald B.,
Veeder Michael H.,
O'Fallon Judith R.,
Vaught Nancy L.,
Dose Ann Marie,
Ghosh Chirantan,
Bartel Joan,
Leitch John M.
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19940801)74:3<945::aid-cncr2820740324>3.0.co;2-c
Subject(s) - medicine , toxicity , crossover study , irritation , fluorouracil , chemotherapy , clinical trial , surgery , ophthalmology , pathology , alternative medicine , immunology , placebo
Background . This clinical trial was developed to determine whether ocular ice pack therapy would decrease 5‐fluorouracil(5‐FU)‐induced ocular toxicity. Methods . Sixty‐two patients who suffered from 5‐FU‐induced ocular toxicity, and were scheduled to receive another cycle of the chemotherapy that caused the ocular toxicity, were entered in this clinical trial. A randomized, crossover design was used, with patients documenting their ocular toxicity by the use of daily diaries. Results . The results from the first cycle of treatment suggested that ocular ice pack therapy decreased 5‐FU‐induced ocular toxicity ( P = 0.056). The 38 evaluable patients in the crossover analyses demonstrated decreased ocular toxicity with ocular ice pack therapy (p = .001). The ocular ice pack therapy was well tolerated by most of the study participants. Conclusion . Ocular ice pack therapy appears to lessen 5‐FU‐induced ocular toxicity to a clinically moderate degree. Better methods for decreasing 5‐FU‐induced ocular toxicity are necessary.