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The role of basement membrane in colorectal cancer invasion and liver metastasis
Author(s) -
Hida JinIchi,
Matsuda Taiji,
Kitaoka Masanori,
Machidera Norikazu,
Kubo Ryuichi,
Yasutomi Masayuki
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19940715)74:2<592::aid-cncr2820740210>3.0.co;2-4
Subject(s) - metastasis , basement membrane , pathology , medicine , colorectal cancer , extracellular matrix , immunohistochemistry , staining , cancer , laminin , liver cancer , type iv collagen , biology , microbiology and biotechnology
Background. Basement membrane (BM) is a specialized extracellular matrix component that plays a key role in tumor invasion and metastasis. Methods. Immunohistochemical staining for two major components of BM, type IV collagen (C IV), and laminin (LN), utilizing avidin‐biotin‐peroxidase complex detection to examine 182 primary colorectal cancers (pT2 or greater) and 20 liver metastases. Results. The distribution of C IV was the same as of LN in colorectal cancer tissue, and in normal tissue. Both C IV and LN staining were more frequently positive in the superficial zone but infrequently in the deep zone of the primary tumor. BM preservation, C IV and LN staining in both the superficial and deep zones, was seen in 18.7% of the subjects. The rate of BM preservation significantly decreased with increasing histologic grade ( P <0.01). No correlation was observed between pT number and BM preservation. The rate of BM preservation in cases of liver metastasis was 84.4%, significantly higher than the rate in cases without liver metastasis ( P <0.001). BM was observed even at the advancing front of tumor invasion and was preserved in 95.0% of the liver metastases. Conclusions. BM is a functional substance that appears to accompany cancer rather than function as a structural barrier against cancer invasion and liver metastasis Cancer 1994; 74:592‐8.