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Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer
Author(s) -
Sukoh Noriaki,
Abe Shosaku,
Ogura Shigeaki,
Isobe Hiroshi,
Takekawa Hironiori,
Inoue Kazuaki,
Kawakami Yoshikazu
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19940701)74:1<46::aid-cncr2820740109>3.0.co;2-g
Subject(s) - immunohistochemistry , medicine , lung cancer , pathology , adenocarcinoma , malignancy , cancer , cathepsin l , cathepsin b , carcinoma , cathepsin , biology , enzyme , biochemistry
Background. The concentration of cysteine proteinase cathepsin B has been shown to be elevated in association with malignancy or metastatic potential of human and rodent tumors, but its prognostic value for human lung cancer remains undetermined. Methods. Using a polyclonal antibody, immunohistochemical analyses of cathepsin B were performed on paraffin embedded sections of tumors obtained surgically from 108 patients with non‐small cell lung cancer (49 squamous cell carcinomas, 59 adenocarcinomas). The immunohistochemical expressions of cathepsin B in the tumors were compared with patient survival. Results. Higher grade expression of cathepsin B was associated significantly with shorter survival in nonsmall cell lung cancer ( P < 0.01), in squamous cell carcinoma ( P < 0.05), and in adenocarcinoma ( P < 0.01). A similar result also was seen in Stage I non‐small cell lung cancer ( P < 0.05). Conclusions. The authors concluded that the immunohistochemical staining pattern of cathepsin B may be a useful predictor of survival for human lung cancer.