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Expression of human nm 23‐H1 and nm 23‐H2 proteins in hepatocellular carcinoma
Author(s) -
Yamaguchi Akio,
Urano Takeshi,
Goi Takanori,
Takeuchi Kazuo,
Niimoto Syuichi,
Nakagawara Gizou,
Furukawa Koichi,
Shiku Hiroshi
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19940501)73:9<2280::aid-cncr2820730908>3.0.co;2-3
Subject(s) - hepatocellular carcinoma , medicine , pathology , protein expression , expression (computer science) , cancer research , computational biology , genetics , biology , gene , computer science , programming language
Background. The expression of nm 23‐H1 and nm 23‐H2 proteins in 25 hepatocellular carcinomas was studied immunohistochemically. Methods. Tissue specimens were reacted with anti‐human nm 23‐H1 and nm 23‐H2 monoclonal antibodies (MoAb) (H1–229 and H2–206, respectively) and then stained by the biotin‐streptoavidin complex method. Results. Adjacent nontumorous tissues were intensely stained with nm 23‐H1 and nm 23‐H2. Of the 25 hepatocellular carcinomas, 60% were positive for MoAb H1–229, and 68% were positive for MoAb H2–206. These immunoreactivities were most common in the cytoplasm of tumor cells. There was no significant correlation between the expression of nm 23‐H1 protein and tumor size, Edmondson's histopathologic classification, or invasion of the capsule. However, the authors observed an inverse relationship between nm 23‐H1 expression and intrahepatic metastases of hepatocellular carcinomas. There was no significant correlation between the expression of nm 23‐H2 protein and clinicopathologic findings. Only a short survival period was observed in patients with hepatocellular carcinoma with reduced nm 23‐H1 or nm 23‐H2 proteins. Conclusions. The results suggest that nm 23‐H1 protein plays a role in the suppression of intrahepatic metastasis of hepatocellular carcinoma and that the combined expression of nm 23‐H1 is associated with favorable prognosis.