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Familial clustering of malignant germ cell tumors and Langerhans' histiocytosis
Author(s) -
Mandel Mathida,
Toren Amos,
Kende George,
Neuman Yoram,
Kenet Gilli,
Rechavi Gideon
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19940401)73:7<1980::aid-cncr2820730732>3.0.co;2-9
Subject(s) - langerhans cell histiocytosis , medicine , malignant histiocytosis , germ cell tumors , embryonal carcinoma , ovary , germ cell , histiocytosis , pathology , chemotherapy , biology , disease , histiocyte , cellular differentiation , genetics , gene
Three sisters in a family with seven children whose grandmother had an ovarian embryonal carcinoma experienced development of malignant and a malignant–like situation in childhood. Two were diagnosed as having malignant germ cell tumors of the ovary, and the third was found to have Langerhans' histiocytosis. The two girls with germ cell tumor shared an identical human leukocyte antigen, whereas the sister with histiocytosis shared one identical haplotype with them. All three children have been treated successfully with chemotherapy and are doing well off of treatment.