Premium
Prospective investigation of tumor markers and risk assessment in early cancer screening
Author(s) -
Kobayashi Tsuneo,
Kawakubo Tomoko
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19940401)73:7<1946::aid-cncr2820730728>3.0.co;2-f
Subject(s) - medicine , cancer , prospective cohort study , oncology , cancer screening , risk assessment , computer security , computer science
Background . Many researchers have reported that tumor marker diagnosis may not be useful in the early detection of cancer. However, the authors proposed a new diagnostic system using a tumor marker combination assay. Methods . The authors screened an asymptomatic population (2126 subjects) in Japan for early cancer over a 2‐year period (1984–1986) using this tumor marker combination assay. The serum tumor marker combination assay data were analyzed: tumor‐specific tumor markers (carcinoembryonic antigen, carbohydrate 19–9, heatstable alkaline phosphatase, and tissue polypeptide antigen), tumor‐associated tumor markers (ferritin, the ratio of ferritin to serum iron, immunosuppressive acidic protein, sialic acid), and growth‐related tumor markers (alkaline phosphatase isoenzymes, ribonuclease). The tumor growth levels of the subjects were assessed by the tumor marker combination assay and classified into five tumor stages (Stage I, tumorfree; Stages II‐III, precancer; Stage IV, preclinical cancer; Stage V, suggestive of cancer weighing over 1 g). The follow‐up period was 5–7 years. Results . The percentage of subjects in tumor stages IV and V increased with age, whereas the percentage in tumor stages II and III decreased. The distribution of screenees within each tumor stage was as follows: I, 0.1%; II, 11.8%; III, 58.8%; IV, 24.8%; V, 4.6%. The rate of incidence of cancer for Stages V, VI, III, II and I was 29.5% (28 of 95), 2.7% (14 of 528), 0.7% (9 of 1251), 0.4% (1 of 250), and 0 (0 of 2), respectively. Conclusions . Our tumor stage classification can adequately assess the risk of cancer developing in apparently healthy persons.