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In vivo effects of insulin on tumor and skeletal muscle glucose metabolism in patients with lymphoma
Author(s) -
Minn Heikki,
Lindholm Paula,
Nuutila Pirjo,
Ruotsalainen Ulla,
Teräs Mika,
Juhani Knuuti M.,
Bergman Jörgen
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19940301)73:5<1490::aid-cncr2820730528>3.0.co;2-h
Subject(s) - medicine , skeletal muscle , endocrinology , glucose uptake , insulin , glucose clamp technique , basal (medicine) , carbohydrate metabolism , anabolism , hyperinsulinemia , positron emission tomography , insulin resistance , pancreatic hormone , nuclear medicine
Background. The anabolic properties of insulin have been suggested for use to reverse malnutrition associated with cancer. The host and tumor sensitivities to insulin are critical for such treatments, which aim to improve patient nutrition. The authors studied insulin effects on tumor and skeletal muscle metabolism with 2‐[ 18 F]‐fluoro‐2‐deoxy‐D‐glucose ([ 18 F]FDG) and positron emission tomography (PET). Methods , Six patients with lymphoma twice underwent [ 18 F]FDG‐PET imaging: once after fasting overnight and once during euglycemic hyperinsulinemic clamp. The dynamic uptake of the glucose analogue [ 18 F]FDG was measured in diseased nodes and upper arm skeletal muscle in both metabolic states. The [ 18 F]FDG uptake in muscle and the whole body glucose use during euglycemic hyperinsulinemic clamp were compared with those of weight‐matched healthy subjects studied under similar circumstances. Results. In lymphomatous tissue, [ 18 F]FDG uptake rates were similar in overnight fasting and euglycemic hyperinsulinemic clamp (38 ± 10 versus 41 ± 9 μmol/100 g/minute, not significant), whereas glucose uptake in skeletal muscle was increased by insulin (1.7 ± 0.2 versus 3.8 ± 0.5 μmol/100 g/minute, P = 0.012). Both basal (2.3 ± 0.2 μmol/100 g/minute, P = 0.061) and insulin‐stimulated (8.5 ± 1.9 μmol/100 g/minute, P = 0.055) skeletal arm muscle glucose uptake rates were higher in control subjects than in patients. Whole body glucose use was 55% lower in patients than in control subjects (17 ± 3 μmol/kg/minute versus 38 ± 3 μmol/kg/minute, P = 0.002), consistent with insulin resistance in cancer. Conclusions. We found that insulin does not induce major changes in glucose uptake of lymphomatous tissue. Although insulin sensitivity of skeletal muscle was also reduced in patients with lymphoma, the net insulin effect may counteract imbalance between glucose uptake of tumor and muscle, offering a potential means to circumvent at least some metabolic abnormalities found in cancer. Cancer 1994; 73:1490–8.