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Omental‐mesenteric inflammatory pseudotumor. Cytogenetic demonstration of genetic changes and monoclonality in one tumor
Author(s) -
Treissman Simon P.,
Alexander Gillis D.,
Giacomantonio Michael,
Lee Christine L. Y.,
Resch Lothar
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19940301)73:5<1433::aid-cncr2820730518>3.0.co;2-f
Subject(s) - inflammatory pseudotumor , medicine , etiology , pathology , plasma cell granuloma , lesion , neoplasm , granuloma , chromosome , biology , biochemistry , gene
Background. Extrapulmonary inflammatory pseudotumor (plasma cell granuloma) is an uncommon lesion in adults and children, and little is known either of its etiology or clinical characteristics. However, it remains a significant source of morbidity to patients and confusion to clinicians. Methods. Case reports are presented of three patients with intraabdominal inflammatory pseudotumor who recently underwent surgery. A review of the recent world literature is also presented. Clinical and laboratory characteristics of omental‐mesenteric inflammatory pseudotumor are reviewed along with a discussion of its etiology. Results. Cytogenetic data from cells of one patient show a derivative chromosome evolved from a translocation between the long arm of chromosome 2 and the short arm of chromosome 9 [(2;9) (q1,3;p2,2)]. Conclusions. The lesion is monoclonal, and genetic changes may play a crucial role in the development of this neoplasm. Omental‐mesenteric inflammatory pseudotumor appears to represent a distinct clinicopathologic entity as a benign neoplasm in children. Cancer 1994; 73:1433–7.