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Overview of clinical radioimmunodetection of human tumors
Author(s) -
Larson Steven M.,
Divgi Chaitanya R.,
Scott Andrew M.
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19940201)73:3+<832::aid-cncr2820731313>3.0.co;2-x
Subject(s) - medicine , immunogenicity , cancer , cancer detection , medical physics , immune system , nuclear medicine , immunology
The role of radioimmunodetection in the detection of cancer has been established through the development of high affinity immunoconjugates and recent improvements in radiochemistry. Advances in imaging techniques, particularly single‐photon emission computed tomography and image registration, also have dramatically improved the sensitivity and accuracy of tumor detection. Molecular engineering of immune constructs provides promise of enhanced tumor localization properties and reduced immunogenicity, allowing repeated studies to be performed. The role of radioimmunodetection in the evaluation of cancer patients will increase in importance in the future. Cancer 1994; 73:832–5.