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Low rate of ret proto‐oncogene activation (PTC/ret TPC ) in papillary thyroid carcinomas from saudi arabia
Author(s) -
Zou Minjing,
Shi Yufei,
Farid Nadir R.
Publication year - 1994
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19940101)73:1<176::aid-cncr2820730130>3.0.co;2-t
Subject(s) - oncogene , thyroid carcinoma , carcinogenesis , cancer research , population , medicine , thyroid , adenoma , cancer , pathology , cell cycle , environmental health
Background. The ret proto‐oncogene activation (PTC/ ret TPC oncogene) in thyroid papillary carcinoma has been reported in different populations with different frequencies. Thyroid papillary carcinoma appears to behave more aggressively in the Persian Gulf region than elsewhere. In the current study, the frequency of PTC/ ret TPC oncogene in thyroid tumors from Saudi Arabia was investigated. Methods. PTC/ ret TPC oncogene transcripts were analyzed by the polymerase chain reaction amplification of cDNA synthesized by treatment of total RNA with reverse transcriptase. Seven multinodular goiters, 1 follicular adenoma, 4 follicular carcinomas, 40 papillary carcinomas, and 5 anaplastic carcinomas were studied. Results. Only one papillary carcinoma specimen was found to have PTC/ ret TPC oncogene transcripts. The breakpoint of the rearranged PTC/ ret TPC oncogene is identical to that previously described. The PTC/ ret TPC ‐positive sample was also examined for p53 tumor suppressor gene mutations in exons 5–8. One transitional point mutation was detected at codon 161 (GCC to ACC), changing Ala to Thr. Conclusions. This study questions the relevance of PTC/ ret TPC oncogene in the carcinogenesis of thyroid papillary carcinomas in the Saudi population. Genetic background among races may contribute to the different frequencies of PTC/ ret TPC oncogene in thyroid papillary carcinoma.