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Reversal of multidrug resistance to cancer chemotherapy
Author(s) -
LeylandJones Brian,
Dalton William,
Fisher George A.,
Sikic Branimir I.
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19931201)72:11+<3484::aid-cncr2820721615>3.0.co;2-l
Subject(s) - multiple drug resistance , medicine , cancer chemotherapy , chemotherapy , phenotype , p glycoprotein , cancer , gene , disease , function (biology) , cancer research , drug resistance , biology , genetics
In the past few years, the role of membrane‐bound transport genes in human disease has been increasingly recognized and understood. Of these genes, the p170 membrane glycoprotein may function as an outward transport pump for many cancer chemotherapeutic drugs associated with the multidrug resistance phenotype. This article reviews the different classes of the current major modulators of multidrug resistance.