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High‐dose chemotherapy with autologous bone marrow transplantation in the treatment of advanced gastric cancer
Author(s) -
Suzuki Takao,
Ochiai Takenori,
Nagata Matsuo,
Koide Yoshio,
Gunji Yoshio,
Nakajima Kazuaki,
Isono Kaichi,
Yokoyama Takeo,
Kashiwabara Hidehiko
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19931101)72:9<2537::aid-cncr2820720905>3.0.co;2-5
Subject(s) - medicine , etoposide , carboplatin , cisplatin , chemotherapy , cancer , surgery , bone marrow suppression , bone marrow , oncology
Background . Clinical usefulness of high‐dose chemotherapy with autologous bone marrow transplantation (ABMT) in the treatment of gastric cancer was investigated. Methods . Ten patients with late‐stage gastric cancer (four recurrent and six primary cases) with measurable lesions were treated with high‐dose combination therapy consisting of etoposide (VP‐16) (1200 mg/m 2 ), adriamycin (80 mg/m 2 ), and cisplatin (120 mg/m 2 ) or carboplatin (900 mg/m 2 ) (high‐dose etoposide, adriamycin, and cisplatin [EAP] therapy). Afterward, 1 × 10 7 /kg of mononuclear cells, which were prepared from autologous bone marrow before treatment and cryopreserved, were transfused intravenously. Results . All patients recovered from the aplastic period without severe complications. Of nine assessable cases, partial response was observed in eight (89% response rate). Conclusion . High‐dose EAP therapy with ABMT is recommended as adjuvant therapy accompanied with radical operation for late‐stage gastric cancer.