Premium
A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5‐fluorouracil‐related stomatitis
Author(s) -
Rocke Luann K.,
Loprinzi Charles L.,
Lee Jeraldine K.,
Kunselman Susan J.,
Iverson Rita K.,
Finck Gwen,
Lifsey Deborah,
Glaw Kara C.,
Stevens Barbara A.,
Hatfield Alan K.,
Vaught Nancy L.,
Bartel Joan,
Pierson Nancy
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19931001)72:7<2234::aid-cncr2820720728>3.0.co;2-n
Subject(s) - cryotherapy , medicine , mucositis , stomatitis , regimen , fluorouracil , chemotherapy , randomized controlled trial , surgery , clinical trial , bolus (digestion) , gastroenterology
Background . The authors previously reported that 30 minutes of oral cryotherapy inhibits 5‐fluorouracil (5‐FU)‐induced stomatitis. The current trial was designed to determine whether a longer duration of cryotherapy would provide additional protection. Methods . This trial involved patients who were receiving their first course of a 5‐FU plus leucovorin chemotherapy regimen, for which stomatitis is a major doselimiting toxicity. These patients were randomized to receive either 30 or 60 minutes of oral cryotherapy given at around the same time as the 5‐FU therapy. Results . A total of 178 evaluable patients were studied. Both cryotherapy groups had similar degrees of mucositis. Conclusion . The authors continue to recommend the use of 30 minutes of oral cryotherapy for patients receiving bolus intensive courses of 5‐FU‐based chemotherapy.