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Parathyroid hormone‐related protein in gastric cancers with heterotopic ossification
Author(s) -
YamamuraIdei Yuka,
Kitazawa Sohei,
Kitazawa Riko,
Fujimori Takahiro,
Chiba Tsutomu,
Maeda Sakan
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930915)72:6<1849::aid-cncr2820720610>3.0.co;2-h
Subject(s) - heterotopic ossification , medicine , ossification , malignancy , immunohistochemistry , pathology , stroma , cancer , staining , heterotopic bone , anatomy
Background . Parathyroid hormone‐related protein (PTHrP) has been regarded as one of the substances causing humoral hypercalcemia of malignancy. Methods . The immunohistochemical localization of PTHrP was investigated in 33 cases of gastric cancer (4 with heterotopic ossification and 29 without heterotopic ossification) to clarify the role of PTHrP in heterotopic ossification by using the anti‐PTHrP monoclonal antibody, 4B3. Results . The four cases with heterotopic ossification showed positive staining at primary or metastatic sites, and in one case fibroblasts in the stroma surrounding the heterotopic ossifying foci also showed positive. On the other hand, of the 29 cases without heterotopic ossification, only 5 showed positive staining. Conclusions . The presence of PTHrP in ossifying gastric carcinomas at a relatively high rate indicates that PTHrP also might be related to heterotopic ossification associated with malignancies. It is speculated that PTHrP would contribute to heterotopic ossification by facilitating the process of mineralization.