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Bilateral multicentric papillary renal tumors with heteroclonal origin based on tissue‐specific karyotype instability
Author(s) -
Henn Wolfram,
Zwergel Thomas,
Wullich Bernd,
Thönnes Monika,
Zang Klaus D.,
Seitz Gerhard
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930815)72:4<1315::aid-cncr2820720427>3.0.co;2-#
Subject(s) - karyotype , pathology , chromosome instability , trisomy , aneuploidy , chromosome , carcinogenesis , biology , cytogenetics , medicine , cancer , genetics , gene
Background . Papillary chromophilic renal tumors were cytogenetically characterized by combined trisomies 7 and 17 along with other numeric chromosome aberrations. They occurred as bilateral multifocal lesions. Methods . A patient was presented who simultaneously developed bilateral multicentric papillary renal tumors. Tissue specimens from six tumors and tumor‐free kidneys were cytogenetically characterized. Results . The tumors showed trisomy of chromosomes 7, 16, and 17 along with various other numeric abnormalities. In normal tissue from both kidneys, a wide variety of clonal and nonclonal numeric and structural chromosome aberrations were found. Conclusions . The cytogenetic heteroclonality of the tumors strongly favors the assumption that they arose as independent primaries. A tissue‐specific karyotype instability may be the basic event of multiple tumorigenesis.