Premium
Significance of aneuploid stemlines in testicular nonseminomatous germ cell tumors
Author(s) -
de Graaff Willem E.,
Sleijfer Dirk Th.,
de Jong Bauke,
Dam Anke,
Koops Heimen Schraffordt,
Oosterhuis J. Wolter
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930815)72:4<1300::aid-cncr2820720424>3.0.co;2-o
Subject(s) - stage (stratigraphy) , medicine , flow cytometry , germ cell , disease , aneuploidy , clinical significance , oncology , pathology , gynecology , immunology , biology , genetics , chromosome , paleontology , gene
Background . Hyperpentaploidy in testicular nonse‐minomatous germ cell tumors (TNSGCT) has been associated with progression of disease of patients who initially had TNSGCT in Stage I. Methods . The authors used flow cytometry to investigate the relationship between ploidy and the clinical behavior in TNSGCT, focusing on hypertetraploid values (DNA index, > 2.00). Results . Patients with TNSGCT containing an aneuploid stemline with a hypertetraploid value more often had higher clinical stage of disease and a higher chance of relapse in advanced stages. The presence of multiple aneuploid stemlines in the tumors was found more frequently in patients who had higher clinical stage disease. Conclusions . The results suggest that the presence of highly aneuploid or multiple aneuploid stemlines in TNSGCT are associated with a clinically more malignant behavior.