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Gliosarcoma with features of chondroblastic osteosarcoma
Author(s) -
Hayashi Kazuhiko,
Ohara Nobuya,
Jeon Ho Jong,
Akagi Seiji,
Takahashi Kiyoshi,
Takahashi Kiyoshi,
Akagi Tadaatsu,
Namba Shimpei
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930801)72:3<850::aid-cncr2820720334>3.0.co;2-4
Subject(s) - gliosarcoma , osteoid , histogenesis , pathology , osteosarcoma , glial fibrillary acidic protein , immunohistochemistry , vimentin , medicine , bone sialoprotein , anatomy , biology , glioblastoma , cancer research , alkaline phosphatase , osteocalcin , biochemistry , enzyme
Background . The occurrence of osteoid‐chondral elements in gliosarcoma is extremely rare and has been reported in only two cases. A new, rare case of gliosarcoma with osteosarcomatous differentiation in a 55‐year‐old man and histogenesis of osteoid‐chondral tissue in gliosarcoma is discussed. Methods . Surgically removed tumor tissues were examined immunohistochemically and electron microscopically, and a histologic examination was performed. Results . Immunohistochemical and electron microscopic studies confirmed the presence of glial, fibroblastic, and osteoid‐chondral elements. A major part of the sarcomatous tissue was undifferentiated and stained only by vimentin. Some areas of osteoid‐chondral tissue were positive for glial fibrillary acidic protein (GFAP). Conclusions . These data suggest that osteoid‐chondral elements came from the sarcomatous portion and GFAP positivity is not restricted to astrocytes and has been seen particularly in chondroid areas of non‐glial tumors.