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CD7+ stem cell leukemia/lymphoma. Features of a subgroup without circulating blast cells
Author(s) -
Katsuno Makoto,
Abe Yasunobu,
Taguchi Fumihiro,
Yufu Yuji,
Sadamura Singo,
Goto Taturo,
Takatsuki Hiroshi,
Nishimura Junji,
Hirata Johji,
Akiyoshi Tomi,
Kimura Nobuhiro,
Nawata Hajime
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930701)72:1<99::aid-cncr2820720119>3.0.co;2-c
Subject(s) - immunophenotyping , medicine , lymphoma , bone marrow , leukemia , pathology , stem cell , clone (java method) , haematopoiesis , cancer research , immunology , biology , antigen , dna , genetics
Recent advances in immunology have clarified the cellular origin of hematopoietic neoplasms. Blast cells with a CD7+ CD4‐ CD8‐ phenotype are demonstrated to originate from malignant pluripotent hematopoietic stem cells. In this article, the authors describe three rare cases, designated as a lymphoma type of CD7+ stem cell leukemia/lymphoma, with clinical features described below. All three patients were admitted with non‐Hodgkin lymphoma with a 2‐month to 4‐month history of lymphadenopathy. Histologic examination of lymph nodes showed lymphoblastic lymphoma (LBL) in all patients. Bone marrow blast cells had an immunophenotype consistent with CD7+ CD4‐ CD8‐ acute leukemia, although abnormal cells were not observed in the peripheral blood during the course of the disease. One patient had a recurrence in the bone marrow, with myeloperoxidase‐positive blast cells expressing myeloid differentiation antigens. Chromosomal analysis detected a common abnormal karyotype initially and at relapse. Furthermore, the same T‐cell receptor gene rearrangement was found initially and at relapse, suggesting that these blast cells originated from the same pluripotent leukemic clone. Additional studies on more patients are required to determine the clinical significance of this group, including the difference from CD7+ stem cell leukemia/lymphoma with circulating blast cells (leukemic type) or LBL. Cancer 1993; 72:99–104.