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Positron emission tomography with fluorine‐18‐deoxyglucose in the detection and staging of breast cancer
Author(s) -
Nieweg Omgo E.,
Kim E. Edmund,
Wong WaiHoi,
Broussard William F.,
Singletary S. Eva,
Hortobagyi Gabriel N.,
Tilbury Roy S.
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930615)71:12<3920::aid-cncr2820711220>3.0.co;2-n
Subject(s) - medicine , breast cancer , positron emission tomography , deoxyglucose , cancer , lymph node , chemotherapy , radiology , primary tumor , mammary gland , nuclear medicine , oncology , metastasis
Background . An increasing number of patients with breast cancer is being treated with preoperative chemotherapy. Evaluation of treatment response may be facilitated by positron emission tomography (PET) with 18 F‐fluoro‐2‐deoxy‐D‐glucose (FDG). This noninvasive technique may allow prediction of the chemotherapy outcome in an early phase of the treatment. Methods . Prerequisites for treatment monitoring with PET are good FDG uptake in the tumor, high specificity, and a reliable quantification technique. These factors were studied in 20 patients with primary breast cancer, lymph node metastases, benign breast lesions, a combination of these abnormalities, or no abnormality. Results . In 10 of 11 patients with primary breast cancer, the tumor was visualized. The median tumor‐to‐normal‐tissue‐uptake ratio was 4.9. In all five patients with increased uptake in the lymphmode basin, pathologic proof of metastatic cancer was found. Of the patients with benign or no disease of the breast, slightly increased uptake was seen in one patient with fibrocystic disease. Conclusion . It is concluded that PET with FDG can be used for breast cancer imaging and staging.