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Expression of the CD15 antigen in hepatocellular carcinoma
Author(s) -
Torii Akihito,
Nakayama Atsuo,
Harada Akio,
Nakao Akimasa,
ami Toshiaki,
Sakamoto Junichi,
Watanabe Tadashi,
Ito Masafumi,
Takagi Hiroshi
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930615)71:12<3864::aid-cncr2820711212>3.0.co;2-5
Subject(s) - cd15 , hepatocellular carcinoma , medicine , metastasis , immunohistochemistry , pathology , antigen , cancer research , cancer , immunology , biology , stem cell , genetics , cd34
Expression of the CD15 antigen, which is one of the adhesion molecules, was studied immunohistochemically to investigate the mechanism of intrahepatic metastasis in 56 hepatocellular carcinomas (HCC). Twenty‐nine percent (16 of 56) of the HCC expressed CD15. No noncancerous hepatocytes expressed CD15. CD15‐positive HCC had histologic intrahepatic metastasis more often than did CD15‐negative HCC; the difference was statistically significant ( P < 0.02). The survival rate of patients with CD15‐negative HCC was better than that of patients with CD15‐positive HCC, although the difference was not statistically significant. The authors speculate that there is a relationship between the expression of CD15 and intrahepatic metastasis in HCC.