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Aberrations of chromosome segment 12q13–15 characterize a subgroup of hemangiopericytomas
Author(s) -
Mandahl Nils,
Örndal Charlotte,
Heim Sverre,
Mitelman Felix,
Willén Helena,
Rydholm Anders,
Bauer Henrik C. F.
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930515)71:10<3009::aid-cncr2820711020>3.0.co;2-y
Subject(s) - hemangiopericytoma , synovial sarcoma , pathology , karyotype , medicine , cytogenetics , chromosome , trisomy , sarcoma , biology , genetics , gene
Background . In later years, several characteristic acquired chromosomal aberrations have been identified in mesenchymal tumors. Many of these aberrations, either alone or with histopathologic and clinical data, are useful in diagnosis. The cytogenetic profile of hemangio‐pericytomas has been poorly investigated. Methods . Short‐term cultures from four spindle cell tumors were cytogenetically analyzed. Results . Clonal acquired chromosome aberrations were found in three of the four tumors: inv(12) (q14q24) in a malignant hemangiopericytoma, a supernumerary der(3)t(3;12) (p21–23;q13–15) in a benign hemangiopericytoma, and t(6;12;19) (p21;q13;p13) in a spindle cell sarcoma that was histologically a malignant hemangiopericytoma or a synovial sarcoma. The fourth tumor, a malignant hemangiopericytoma, had a normal karyotype. The tumors with inv(12) and t(6;12;19) had subclones with trisomy 5 in addition to the structural changes. Conclusions . The current findings and the literature data indicate that a subgroup of hemangiopericytomas is characterized by rearrangement of chromosome segment 12q13–15.