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Pulmonary granulomata. A complication of intravesical administration of bacillus calmette‐guerin for superficial bladder carcinoma
Author(s) -
Smith Robert L.,
Alexander Robert F.,
Aranda Conrado P.
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930301)71:5<1846::aid-cncr2820710521>3.0.co;2-o
Subject(s) - medicine , complication , carcinoma , lung , biopsy , urinary bladder , granuloma , bcg vaccine , infiltration (hvac) , pathology , surgery , urology , tuberculosis , physics , thermodynamics
Intravesical administration of bacillus Calmette‐Guerin (BCG) is an effective treatment for superficial carcinoma of the bladder. The authors report a pulmonary complication characterized by miliary infiltration on chest roentgenogram and caseating granulomata on lung biopsy specimens. This case and three prior reports suggest that this complication may be a form of hypersensitivity rather than true BCG infection.