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Results of salvage mastectomy for local recurrence after breast‐conserving surgery without radiation therapy
Author(s) -
Cajucom Conrad C.,
Tsangaris Theodore N.,
Nemoto Takuma,
Driscoll Deborah,
Penetrante Remedios B.,
Holyoke E. Douglas
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930301)71:5<1774::aid-cncr2820710511>3.0.co;2-v
Subject(s) - medicine , mastectomy , radiation therapy , salvage surgery , salvage therapy , breast conserving surgery , surgery , breast cancer , oncology , cancer , chemotherapy
Background . Between 1975 and 1987, 128 patients with infiltrating breast cancer, categorized as clinical Stage I and II disease, were treated by breast conservation surgery without radiation therapy. Materials . After a median disease‐free interval of 20 months (range, 8–64 months), 25 of 128 patients had local recurrence, for which salvage mastectomy was performed. The results of modified radial mastectomy as a salvage procedure were analyzed in these 25 patients. Results . After a median disease‐free interval of 52 months (range, 8–75 years) after the salvage procedure, 12 patients had chest wall and distant recurrences, whereas 13 patients remained free of disease. The 5‐year actuarial disease‐free and overall survival rates after the salvage mastectomy were 51% and 65%, respectively. Conclusions . Univariate analyses of factors affecting disease‐free survival and overall survival showed that the size of the local recurrence (≤ 2 cm) ( P = 0.009) and the number of pathologically positive axillary nodes at the time of the salvage procedure (fewer than four nodes) ( P = 0.002) were associated with a better prognosis.