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Laminin distribution patterns are closely related to liver metastasis in gastric cancer
Author(s) -
Orita Hiroyuki,
Korenaga Daisuke,
Maehara Yoshihiko,
Baba Hideo,
Sugimachi Keizo
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930215)71:4<1201::aid-cncr2820710405>3.0.co;2-8
Subject(s) - medicine , cancer , metastasis , laminin , oncology , pathology , cancer research , microbiology and biotechnology , biology , extracellular matrix
Background . Laminin is the major glycoprotein of basement membrane and is known to have an important role in the metastatic process. Methods . The authors used immunohistochemical techniques to evaluate the distribution of laminin‐containing basement membrane in specimens from 157 patients with advanced gastric cancer. Results . This membrane was found less frequently in the deep periphery than in the mucosa. According to our classification of distribution patterns, 39 (24.8%) tumors had laminin in the mucosa and the deep periphery of tumor (Group A); 37 (23.6%) tumors had laminin in the mucosa but not in the periphery (Group B); and in 81 (51.6%) tumors laminin was not found in the mucosa or the periphery (Group C). Tumors with laminin in the deep periphery (Group A) were characterized by expansive growth ( P < 0.05), and there was a significant correlation with the occurrence of vessel invasion ( P < 0.05) and liver metastasis ( P < 0.01). Patients with Group A tumors had poor prognosis compared with patients with Group C tumors ( P < 0.05). Multivariate logistic regression analysis showed laminin distribution patterns to be an independent value for predicting liver metastasis, as are lymph node involvement and expansive growth. Conclusion . The authors propose that laminin‐positive basement membrane in the deep periphery in gastric cancer tissue is a significant risk factor for liver metastasis. For such high‐risk patients, close follow up and post‐operative adjuvant therapy are required.