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Immune‐mediated thrombocytopenia secondary to suramin
Author(s) -
Seidman Andrew D.,
Schwartz Michael,
Reich Lillian,
Scher Howard I.
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930201)71:3<851::aid-cncr2820710331>3.0.co;2-m
Subject(s) - suramin , medicine , plasmapheresis , immune system , immunology , renal cell carcinoma , coagulation , antibody , receptor
The authors report a case of suramin‐induced immune‐mediated thrombocytopenia occurring in a patient on a Phase II protocol for treatment of metastatic renal cell carcinoma. On withdrawal of suramin, the acute and severe thrombocytopenia did not respond initially to plasmapheresis; subsequently, it resolved promptly and dramatically during the administration of intravenous gamma globulin, also coinciding with a decline in suramin blood levels. Results of immunologic and coagulation studies are reported and clinical implications discussed.