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Endocrine therapy of advanced carcinoma of the prostate
Author(s) -
Daneshgari Firouz,
Crawford E. David
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930201)71:3+<1089::aid-cncr2820711431>3.0.co;2-h
Subject(s) - medicine , prostate cancer , prostate , hormone , endocrine system , androgen , hormonal therapy , cancer , disease , oncology , refractory (planetary science) , palliative therapy , physics , astrobiology
Increasing evidence suggests that growth of the prostatic tissue is regulated by a network of hormones and growth factors, in which androgens play the prominent role. Hormonal manipulation remains the core of treatment for locally advanced and metastatic prostate cancer. Achievement of a complete androgen blockade, by surgical or medical means or a combination of both, offers superior results in palliative management of advanced disease. Management of hormonal refractory cancer, however, remains a challenge to clinicians.