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Aromatase activity in human hepatocellular carcinoma relationship with the degree of histologic differentiation
Author(s) -
Yabuuchi Iwao,
Kawata Sumio,
Tamura Shinji,
Ito Nobuyuki,
Matsuda Yasuo,
Nishioka Minoru,
Moriwaki Kaname,
Matsuzawa Yuji,
Tarui Seiichiro
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930101)71:1<56::aid-cncr2820710110>3.0.co;2-0
Subject(s) - aromatase , hepatocellular carcinoma , medicine , microsome , endocrinology , androgen , estrogen , carcinoma , pathology , enzyme , biology , cancer , hormone , breast cancer , biochemistry
Human hepatocellular carcinomas (HCC) were examined aromatase activity, an enzyme that converts androgen into estrogen. Such activity was detected in all 13 specimens of HCC (mean activity, 120 fmol/30 min/mg microsomal protein). The activity tended to be lower in the HCC tissue than in the surrounding liver tissue (mean activity, 230 fmol/30 min/mg microsomal protein), although it was higher in the HCC tissue from three of eight patients with Edmondson's Grade 2 disease. This relationship was not found in the five with Grade 3 disease. On the whole, aromatase activity was significantly higher in specimens from patients with Edmondson's Grade 2 tumors than in the less differentiated Grade 3 type ( P < 0.05). These observations suggested that aromatase activity was present in human HCC and was related to the degree of histologic differentiation. Cancer 1993; 71:56‐61.