Premium
Specific skin manifestations in acute leukemia with monocytic differentiation a morphologic and immunohistochemical study of 11 cases
Author(s) -
Sepp Norbert,
Radaszkiewicz Thaddäus,
Meijer Chris J. L. M.,
Smolle Josef,
Seewann Helmut,
Fritsch Peter,
Kerl Helmut
Publication year - 1993
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19930101)71:1<124::aid-cncr2820710120>3.0.co;2-h
Subject(s) - medicine , acute monocytic leukemia , cd15 , pathology , monocytic leukemia , monocytosis , cd68 , cd20 , leukemia , acute myelomonocytic leukemia , acute leukemia , immunohistochemistry , immunology , bone marrow , cd34 , biology , stem cell , genetics
Background . Monocytic differentiation is present in the myelomonocytic (M4) and monocytic (M5) type of acute myeloblastic leukemia. Infiltration of the skin in acute myelomonocytic leukemia occurs in 10–20% of patients, the skin lesions occasionally being the first symptom, even preceding monocytosis. Methods . Eleven patients with myelomonocytic (n = 2) and monocytic leukemia (n = 9) were studied who had skin manifestations. Results and Conclusions . Clinically, all patients showed disseminated papules or nodules that corresponded histologically to nodular or diffuse infiltrates of monocytoid cells, occasionally displaying a whorled pattern. The currently available antibodies for paraffin‐embedded sections (lysozyme), elastase, leukocyte common antigen (CD45), MT1 (CD43), Leu‐Mi (CD15), LN2 (CD74), MB2, MB1 (CD45RA), LN1 (w75), Mac387, L26 (CD20), UCHL1 (CDR0), MT2 (CD45RA), and KP‐1 (CD68)) and chloracetate–esterase are not more helpful in diagnosis than are the histologic findings. By contrast, the antibodies used on frozen sections (Leu‐4 (CD3), Leu‐3a (CD4), BA1 (CD24), B4 (CD19), Leu‐M5 (CD11c), Vim12 (CD11b), VimD5 (CD15), KiM6 (CD68), KIM7 (CD68), My7 (CD13), and My9 (CD33) allow the definition of a reaction pattern that is diagnostic for acute myeloid leukemia with monocytic differentiation. Cancer 1993; 71:124‐32.