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Prognostic factor of telecobalt therapy for early glottic carcinoma
Author(s) -
Inoue Takehiro,
Inoue Toshihiko,
Ikeda Hiroshi,
Teshima Teruki,
Murayarna Shigeyuki
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19921215)70:12<2797::aid-cncr2820701212>3.0.co;2-5
Subject(s) - medicine , glottis , carcinoma , laryngeal neoplasm , oncology , larynx , surgery
Background . Local control rates of T1 and T2 glottic carcinoma treated with radiation alone were reported as 80–91% and 63–76%, respectively. The authors investigated the factors that affect the local control rate for early glottic carcinoma. Methods . From 1967 through 1982, 330 patients with early glottic carcinoma (T1: 274 patients; T2: 56) were treated with telecobalt therapy at the Department of Radiology, Osaka University Hospital, Osaka, Japan. Results . Five‐year actuarial survival rates of patients with T1 and T2 were 79% and 80%, respectively. Five‐year local disease control rates of patients with T1 and T2 disease were 81% and 67%, respectively. In 243 of 254 patients treated with 2 Gy a day, tumor response could be evaluated at the dose level of 40 Gy. For tumors treated with a daily dose of 2 Gy, local control rates of 153 tumors that disappeared at 40 Gy and 90 tumors that persisted at 40 Gy were 83% and 62%, respectively (P < 0.001). Field size and daily fraction size did not affect the local control rate. Conclusion . Evaluation of tumor response at 40 Gy was an important indicator of local disease control for early glottic cancers treated with 2 Gy a day.