Premium
Primary small cell carcinoma of the vagina arising in a background of atypical adenosis
Author(s) -
Prasad Chaya J.,
Ray Judith A.,
Kessler Stephen
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19921115)70:10<2484::aid-cncr2820701015>3.0.co;2-o
Subject(s) - vagina , medicine , vulva , pathology , immunohistochemistry , cervix , carcinoma , ovary , chromogranin a , anatomy , cancer
Background. Primary small cell carcinoma of the vagina is rare, with only nine cases published to date. The authors report what they believe to be the first case of primary small cell carcinoma of the vagina arising in a setting of atypical adenosis. Methods. The tumor was studied by light and electron microscopy and immunohistochemistry. Results. Intracytoplasmic electron‐dense neurosecretory type granules were seen, and immunohistochemical demonstration of chromogranin A was documented. Conclusions. These features were found to be similar to small cell carcinomas arising elsewhere in the female genital tract (i.e., cevix, endometrium, ovary, and vulva).