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Neuropeptide Y secretion from a malignant extraadrenal retroperitoneal paraganglioma
Author(s) -
Kuvshinof Boris W.,
Nussbaum Michael S.,
Richards Arthur I.,
Bloustein Paul,
McFadden David W.
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19921101)70:9<2350::aid-cncr2820700923>3.0.co;2-8
Subject(s) - medicine , neuropeptide y receptor , paraganglioma , chemotherapy , neuroendocrine tumors , pathology , surgery , gastroenterology , neuropeptide , endocrinology , radiology , receptor
A patient with a malignant extraadrenal retroperitoneal paraganglioma had elevated levels of immunoreactive neuropeptide Y (NPY) in the peripheral blood (5988 pg/ml; normal, 123 ± 30 pg/ml [mean ± standard error of the mean]). A 6‐month course of chemotherapy allowed surgical removal of the previously unresectable primary tumor. Postoperatively, the plasma NPY level initially fell to 1089 pg/ml; continued chemotherapy caused an additional decrease to 440 pg/ml. Four months after surgery, the plasma NPY level increased to 940 mg/ml, coincident with hepatic metastases. This case is the first report of a NPY‐secreting clinically nonfunctional malignant extraadrenal paraganglioma. Determination of circulating NPY levels may be useful in the diagnosis and follow‐up of patients with neuroendocrine tumors. Cancer 1992; 70:2350‐2353.