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Increased secretion of lnterleukin‐6 in malignant mesothelioma cells from a patient with marked thrombocytosis
Author(s) -
Higashihara Masaaki,
Sunaga Shinji,
Tange Tsuyoshi,
Oohashi Hideya,
Kurokawa Kiyoshi
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19921015)70:8<2105::aid-cncr2820700816>3.0.co;2-r
Subject(s) - thrombocytosis , medicine , mesothelioma , pathology , immunohistochemistry , pathogenesis , monocyte , secretion , immunology , platelet
Background . A high prevalence of thrombocytosis in malignant mesothelioma has been reported, although its pathogenesis remains unknown. Methods . The case of a patient with marked thrombocytosis in peritoneal malignant mesothelioma is reported. To investigate the cytokines responsible for thrombocytosis in this patient, enzyme‐linked immunosorbent assay and immunohistochemical analysis were used. Results . Tumor cells produced large amounts of in‐terleukin‐6 (IL‐6) and small amounts of granulocyte macrophage colony stimulating factor (GM‐CSF) and monocyte colony stimulating factor (M‐CSF). Immunocytochemical staining of tumor cells showed strong positivity for IL‐6. Conclusions . These results indicated that persistant secretion of IL‐6 promoted thrombogenesis in this patient.