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Evidence for an association between hairy cell leukemia and renal cell and colorectal carcinoma
Author(s) -
Nielsen Bendt,
Braide Inger,
Hasselbalch Hans
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19921015)70:8<2087::aid-cncr2820700813>3.0.co;2-p
Subject(s) - medicine , renal cell carcinoma , colorectal cancer , leukemia , oncology , hairy cell leukemia , pathology , cancer research , cancer
Background . Hairy cell leukemia (HCL) has been associated with several disease states. In this study, a possible association is reported between HCL and renal cell carcinoma (RCC) and colorectal carcinoma (CRC). Methods . A retrospective study of the case records of 50 patients with HCL in a study of α‐interferon (α‐IFN) treatment of HCL. Results . Three of 50 patients with HCL studied had RCC, and 2 of these also had CRC. In addition, two other patients had CRC. The other malignant lesions developed either before or after the diagnosis of HCL. In all patients, the HCL responded to α‐interferon (α‐IFN), but in four patients, the second lesion was diagnosed during IFN treatment. Conclusions . These findings could indicate that IFN does not correct a possible common basic etiologic defect and shows that even early CRC and RCC do not respond to the IFN doses administered. These findings should be considered in future trials of IFN treatment of these diseases. The authors also recommend a reevaluation of the frequency of second malignant lesions in HCL; this may be important particularly with the increased survival in patients with HCL who receive a‐IFN treatment.