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Flow cytometric DNA analysis of gastric smooth muscle tumors
Author(s) -
Shimamoto Takehiro,
Haruma Ken,
Sumii Koji,
Kajiyama Goro,
Tahara Eiichi
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19921015)70:8<2031::aid-cncr2820700803>3.0.co;2-c
Subject(s) - medicine , dna , flow (mathematics) , pathology , flow cytometry , anatomy , mechanics , immunology , genetics , biology , physics
Background . To better understand the malignant grade of gastric smooth muscle tumors, the DNA content of these tumors was studied. Methods . In 43 patients with gastric smooth muscle tumors, the cellular DNA content was determined by flow cytometry and compared with the histologic classification and the prognosis. Results . Flow cytometry indicated that all 21 leiomyomas and 9 of the 10 low‐grade leiomyosarcomas were diploid; 10 of the 12 high‐grade leiomyosarcomas were aneuploid. All patients with leiomyomas and 8 of the 11 patients with diploid leiomyosarcomas had neither local recurrence nor metastasis. By contrast, 8 of the 10 patients with aneuploid leiomyosarcomas died of their disease (mean survival, 41 months; range, 18‐78 months). Conclusions . These results indicate that the DNA ploidy pattern shown by flow cytometry is related closely to the histologic classification and prognosis of gastric smooth muscle tumors.