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Leptomeningeal myelomatosis presenting with mental status changes and other neurologic findings
Author(s) -
Leifer Dana,
Grabowski Thomas,
Simonian Nancy,
Demirjian Zarek N.
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19921001)70:7<1899::aid-cncr2820700716>3.0.co;2-3
Subject(s) - medicine , multiple myeloma , complication , magnetic resonance imaging , cancer , radiology , surgery
Background . Leptomeningeal myelomatosis is a rare complication of multiple myeloma. Methods . The authors identified and studied three patients with leptomeningeal myelomatosis and reviewed previous case reports of this condition. Results . The patients described here had intermittent abnormalities in mental status or cranial nerve and brain stem abnormalities. Two of the patients responded dramatically, though transiently, to treatment. In one patient, the clinical findings correlated with lesions visualized by gadolinium‐enhanced magnetic resonance imaging. Conclusions . These patients are typical of those reported previously. Patients with leptomeningeal myelomatosis often have a good response to treatment initially, but long‐term survival is rare. Cancer 1992; 70:1899‐1904.