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DNA image cytometry in stomach carcinoma. Its relation to histomorphologic parameters and its influence on prognosis
Author(s) -
Böttger T. C.,
Gabbert H.,
Stöckle T. C.,
Wellek S.,
Jauckus C.,
Grenz A.,
Junginger T.
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19921001)70:7<1819::aid-cncr2820700702>3.0.co;2-o
Subject(s) - stomach , medicine , lymph node , carcinoma , signet ring cell carcinoma , stomach cancer , pathology , signet ring cell , cancer , stage (stratigraphy) , gastric carcinoma , dna , gastroenterology , oncology , adenocarcinoma , biology , paleontology , genetics
Background . The influence of DNA content on the prognosis in stomach cancer is controversial. Method . After curative resection of stomach carcinomas (adenocarcinomas [n = 58J]); signet ring cell carcinomas [n = 24J]; undifferentiated carcinomas [n = 21J], the influence of the DNA content and histomorphologic parameters on the prognosis was examined. Results . In the multivariate regression analysis, the prognosis depended on the lymph node status (P = 0.0009), pT stage (P = 0.02), tumor localization (P = 0.03), and histologic type (P = 0.05). The prognosis was independent of the DNA content. Furthermore, the degree of differentiation, operative procedure, safety distance, size of the tumor, and sex and age of the patient also did not influence the prognosis. Conclusions . The DNA content of the tumor cells in stomach carcinoma does not influence prognosis. Cancer 1992; 70:1819–1824.