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Lethal midline granuloma (peripheral T‐cell lymphoma) after lymphomatoid papulosis
Author(s) -
Harabuchi Yasuaki,
Kataura Akikatsu,
Kobayashi Kazutoyo,
Yamamoto Tetsuo,
Yamanaka Noboru,
Hirao Motoyasu,
Onodera Kazufumi,
Kon Shinichiro
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920815)70:4<835::aid-cncr2820700419>3.0.co;2-f
Subject(s) - medicine , lymphomatoid papulosis , lymphoma , pathology , cd30 , population , cutaneous lymphoma , gene rearrangement , skin biopsy , t cell lymphoma , biopsy , immunology , mycosis fungoides , gene , biology , environmental health , biochemistry
A Japanese woman with an 8‐year history of lymphomatoid papulosis (LP) had lethal midline granuloma (LMG) develop at the age of 51 years. There were histologic similarities between LP and LMG seen in this patient. Surface phenotypic studies on nasal and cutaneous lesions demonstrated a population of T‐cells expressing CD2, CD4, CD25, CD30, and histocompatibility antigen‐DR (HLA‐DR). Genotypic analyses of nasal and skin biopsy specimens disclosed a clonal rearrangement of the beta T‐cell receptor gene with the same rearrangement pattern. These data indicate that this patient had LMG characterized by clonal peripheral T‐cell lymphoma, which probably resulted from progression of the LP. Cancer 1992; 70:835–839.