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Prognostic significance of DNA ploidy in male breast carcinoma. A retrospective analysis of 32 cases
Author(s) -
Gattuso Paolo,
Reddy Vijaya B.,
Green Linda,
Castelli Melanie,
Haley David,
Herman Chester
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920815)70:4<777::aid-cncr2820700410>3.0.co;2-z
Subject(s) - medicine , breast carcinoma , aneuploidy , oncology , lymph node , carcinoma , breast cancer , ploidy , multivariate analysis , stage (stratigraphy) , discriminant function analysis , pathology , cancer , biology , chromosome , gene , paleontology , biochemistry , machine learning , computer science
Background . DNA aneuploidy has been prognostically significant in female breast carcinoma of low stage, but its value in male breast carcinoma remains undetermined. Methods . Flow cytometric DNA analyses were performed retrospectively on paraffin‐embedded tissue from 32 men with breast carcinoma (mean follow‐up time, 5.97 years [standard deviation ± 4.631] range, 1 to 18 years). Results . Multivariate discriminant function analysis showed only tumor size less than 2 cm to be independently predictive of better disease‐free survival ( P < 0.05). DNA ploidy (aneuploid, 25 patients; diploid, 7 patients) and lymph node status (positive, 22 patients; negative, 10 patients) were not predictive of survival, regardless of tumor size. Conclusions . The authors concluded that DNA ploidy may not significantly predict survival in male breast carcinoma. Cancer 1992; 70:777–780.