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Cytogenetic characteristics of childhood non‐Hodgkin lymphoma
Author(s) -
Shikano Takaaki,
Ishikawa Yorikazu,
Naito Hiroyuki,
Kobayashi Ryoji,
Nakadate Hisaya,
Hatae Yoshio,
Takeda Takeo
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19920801)70:3<714::aid-cncr2820700329>3.0.co;2-z
Subject(s) - lymphoma , chromosomal translocation , medicine , immunophenotyping , karyotype , non hodgkin's lymphoma , pathology , tetrasomy , cytogenetics , lymphoblastic lymphoma , chromosome , immunology , t cell , biology , flow cytometry , gene , genetics , immune system
Cytogenetic studies were performed successfully on 24 patients with non‐Hodgkin lymphoma (NHL) who were younger than 15 years of age. Of these, 22 patients (92%) had abnormal clones. With respect to histologic findings, 3 (25%) of the 12 patients with lymphoblastic lymphoma had 14q11 translocations and 2 (17%) had t(9;17) (q34;q23). Four (80%) of the five patients with small non‐cleaved cell lymphoma had t(8;14) (q24;q32). With respect to immunologic findings, four (44%) of the nine patients with T‐cell lymphoma had abnormalities consisting of 14q1 and 7q36 translocations, in which the T‐cell receptor genes resided. Three (33%) of the patients with T‐cell lymphoma had t(9;17) (q34;q23). However, three (43%) of the seven patients with B‐cell lymphoma had t(8;14) (q23;q32), and two (29%) of the patients with B‐cell lymphoma had an extra i(11q) chromosome with a resultant 11q tetrasomy. Non‐T‐cell non‐B‐cell lymphomas, which occurred in 21% of all patients, showed various chromosomal abnormalities. This study demonstrated that, in childhood NHL, karyotype correlates closely with immunophenotype, clinical features, and histologic findings. Cancer 1992; 70:714–719.